## Abstract As a continuation of our studies on bicyclic heterocycles with benzodiazepine receptor affinity, derivatives with a 5:5 bicyclic skeleton, namely imidazo[2,1β__b__]thiazoles, imidazo[2,1β__b__]imidazoles and pyrrolo[1,2β__c__]imidazoles were prepared. The compounds possessed an aromatic
Imidazo[2,1-b]thiazepines: Synthesis, Structure and Evaluation of Benzodiazepine Receptor Binding.
β Scribed by Katarzyna Kiec-Kononowicz; Janina Karolak-Wojciechowska; Barbara Michalak; Elzbieta Pekala; Britta Schumacher; Christina E. Mueller
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 90 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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## Abstract A series of arylidene imidazo[2,1β__b__]thiazoles was synthesized, in order to investigate the influence of different spatial arrangements of the arylidene substituent towards the bicyclic structure of imidazo[2,1β__b__]βthiazole on benzodiazepine receptor affinity. 1,2β And 2,3βcyclize
## Abstract The fundamental chemistry of pyridazines, the syntheses of substituted irnidazo[1,2β__b__]pyridazines (1) (and some related compounds) and the interaction of the products with central benzodiazepine receptors (CBR) and peripheralβtype (mitochondrial) benzodiazepine receptors (PBR) are d