✦ LIBER ✦

Imidazo[1,2-b]pyridazines: Syntheses and interaction with central and peripheral-type (mitochondrial) benzodiazepine receptors

✍ Scribed by Gordon B. Barlin

Publisher: Journal of Heterocyclic Chemistry
Year: 1998
Tongue: English
Weight: 900 KB
Volume: 35
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570350515

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The fundamental chemistry of pyridazines, the syntheses of substituted irnidazo[1,2‐b]pyridazines (1) (and some related compounds) and the interaction of the products with central benzodiazepine receptors (CBR) and peripheral‐type (mitochondrial) benzodiazepine receptors (PBR) are described.

Some of these imidazo[1,2‐b]pyridazines had high selective affinity for the central benzodiazepine receptors and others had high selectivity for the peripheral‐type (mitochondrial) benzodiazepine receptors. The results of structure‐activity studies and molecular modeling will be reported.

In vivo tests of some compounds which interacted strongly with the central benzodiazepine receptors revealed reasonably potent anticonvulsant/anticonflict activity, and some of those which bind selectively to the peripheral‐type (mitochondrial) benzodiazepine receptors are being examined as possible radiopharmaceuticals for imaging of tumors (and other disease states).

📜 SIMILAR VOLUMES

ChemInform Abstract: Imidazo[1,2-b]pyrid

ChemInform Abstract: Imidazo[1,2-b]pyridazines: Syntheses and Interaction with Central and Peripheral-Type (Mitochondrial) Benzodiazepine Receptors

✍ Gordon B. Barlin 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 26 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

ChemInform Abstract: Imidazo(1,2-b)pyrid

ChemInform Abstract: Imidazo(1,2-b)pyridazines. Part 22. Syntheses of Some 2-Aryl-3-methoxy- 6-(pyridinylmethylthio and pyridinylmethylamino)imidazo(1,2-b) pyridazines and Their Interaction with Central and Mitochondrial ( Peripheral-Type) Benzodiazepine Receptors.

✍ G. B. BARLIN; L. P. DAVIES; S. J. IRELAND; M. M. L. NGU-SCHWEMLEIN 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views

ChemInform Abstract: Imidazo(1,2-b)pyrid

ChemInform Abstract: Imidazo(1,2-b)pyridazines. Part 21. Syntheses of Some 3- Acylaminomethyl-6-(chloro and iodo)-2-(substituted phenyl)-imidazo(1,2- b)pyridazines and imidazo(1,2-a)pyridines and Their Interaction with Central and Mitochondrial Benzodiazepine Receptors.

✍ G. B. BARLIN; L. P. DAVIES; P. W. HARRISON 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 1 views

ChemInform Abstract: Imidazo[1,2-b]pyrid

ChemInform Abstract: Imidazo[1,2-b]pyridazines. Part 24. Syntheses of Some 3-(Variously Substituted) Imidazo[1,2-b]pyridazines, 6-Substituted 2-Benzoylimidazo[1,2-b]pyridazines and Pyrimido[1,2-b]pyridazin-5-ium-3-olates and Their Interaction with Central and Mitochondrial Benzodiazepine Receptors.

✍ M. SCHMITT; J.-J. BOURGUIGNON; G. B. BARLIN; L. P. DAVIES 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 43 KB 👁 1 views

Interaction of Novel Condensed Triazine

Interaction of Novel Condensed Triazine Derivatives with Central and Peripheral Type Benzodiazepine Receptors: Synthesis, in vitro Pharmacology and Modelling.

✍ Eva Szarics; Zsuzsanna Riedl; Lajos Nyikos; Gyoergy Hajos; Julianna Kardos 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 18 KB

Synthesis and Biological Evaluation of P

Synthesis and Biological Evaluation of Pyridazino[4,3-b]indoles and Indeno[1,2-c]pyridazines as New Ligands of Central and Peripheral Benzodiazepine Receptors.

✍ Francesco Campagna; Fausta Palluotto; Maria Paola Mascia; Elisabetta Maciocco; C 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 164 KB

## Abstract For Abstract see ChemInform Abstract in Full Text.