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Imidaprilat inhibits matrix metalloproteinase-2 activity in human cardiac fibroblasts induced by interleukin-1β via NO-dependent pathway

✍ Scribed by Xiao-Gang Guo; Hiroyasu Uzui; Toshihiro Mizuguchi; Takanori Ueda; Jun-zhu Chen; Jong-Dae Lee


Book ID
116546709
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
506 KB
Volume
126
Category
Article
ISSN
0167-5273

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## Abstract ## Objective To investigate the effects of prostaglandin D~2~ (PGD~2~) on interleukin‐1β (IL‐1β)–induced matrix metalloproteinase 1 (MMP‐1) and MMP‐13 expression in human chondrocytes and the signaling pathways involved in these effects. ## Methods Chondrocytes were stimulated with I