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IMC-A12, a Human IgG1 Monoclonal Antibody to the Insulin-Like Growth Factor I Receptor

✍ Scribed by Rowinsky, E. K.; Youssoufian, H.; Tonra, J. R.; Solomon, P.; Burtrum, D.; Ludwig, D. L.


Book ID
121838480
Publisher
American Association for Cancer Research
Year
2007
Tongue
English
Weight
198 KB
Volume
13
Category
Article
ISSN
1078-0432

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## Abstract A monoclonal antibody of the IgG class, EGFR1, has been isolated using cells of the epidermoid carcinoma line A431 as immunogen. The A431 antigen recognized by EGFR1 has an apparent molecular weight of approximately 175,000, is a cell‐surface molecule which can be specifically cross‐lin