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214 POSTER Characterization of a recombinant, fully human monoclonal antibody directed against the human insulin-like growth factor-1 receptor

✍ Scribed by T. Schnitzer; K.-P. Kuenkele; F. Rebers; M. Van Vugt; C. Klein; M. Lanzendoerfer; O. Mundigl; P.W.H.I. Parren; J.G.J. van de Winkel; R. Schumacher


Book ID
118623842
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
76 KB
Volume
4
Category
Article
ISSN
1359-6349

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## Abstract Interaction of insulin‐like growth factor receptor I (IGF‐IR) with its ligands has been reported to induce cell proliferation, transformation and blockade of cell apoptotic functions. IGF‐IR is overexpressed on numerous tumor cell types and its blockade could be of importance for anti‐c