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Imatinib mesylate for aggressive systemic mastocytosis with long bone osteolysis

✍ Scribed by Anja Gunda Jung; Hans-Peter Horny; Karl Sotlar; Tobias Overbeck; Michael Peter Schön; Undine Lippert


Book ID
116586012
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
454 KB
Volume
65
Category
Article
ISSN
1097-6787

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Gain-of-function D816V point mutation within the kinase domain of the transmembrane receptor KIT is found in the great majority of patients with systemic mastocytosis (SM) and is attractive therapeutic target. Twenty patients with SM were enrolled during 2003-2005 in phase II clinical trial with ima