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Imatinib mesylate responsiveness in aggressive systemic mastocytosis: Novel association with a platelet derived growth factor receptor beta mutation

✍ Scribed by Bakul I. Dalal; Douglas E. Horsman; Hélène Bruyèrè; Donna L Forrest


Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
251 KB
Volume
82
Category
Article
ISSN
0361-8609

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## Abstract ## BACKGROUND. In previous experimental models, because of its ability to inhibit the activity of platelet‐derived growth factor β receptor, imatinib decreased the interstitial fluid pressure and improved the delivery and efficacy of anticancer drugs, including fluorouracil. The object