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Imatinib dose escalation to achieve molecular responses in patients with chronic myeloid leukemia in late chronic phase

✍ Scribed by F. Stagno; P. Vigneri; V. Del Fabro; S. Stella; M. Massimino; S. Berretta; A. Messina; F. Di Raimondo


Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
82 KB
Volume
33
Category
Article
ISSN
0145-2126

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Chronic myeloid leukaemia (CML) patients in chronic phase (CP) are currently treated with a standard dose of imatinib of 400mg/daily. However, once in complete cytogenetic remission (CCR) it is possible that some patients maintain this status with reduced dose of the drug. Here, we describe five cas

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✍ Massimo Breccia; Laura Cannella; Caterina Stefanizzi; Roberto Latagliata; Mauro πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 76 KB

## Abstract Imatinib mesylate is the gold standard treatment of chronic myeloid leukaemia (CML) and 400 mg/day is considered the standard dose. Although it is generally well tolerated, some patients require temporary drug discontinuation and permanent dose reduction because of haematological or non