Imaging of P-glycoprotein–mediated pharmacoresistance in the hippocampus: Proof-of-concept in a chronic rat model of temporal lobe epilepsy
✍ Scribed by Hero Bartmann; Christina Fuest; Christian La Fougere; Guoming Xiong; Theresa Just; Juli Schlichtiger; Petra Winter; Guido Böning; Björn Wängler; Anton Pekcec; Jonna Soerensen; Peter Bartenstein; Paul Cumming; Heidrun Potschka
- Book ID
- 109112796
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2010
- Tongue
- English
- Weight
- 492 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0013-9580
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## Abstract Degeneration of the CA3 pyramidal and dentate hilar neurons in the adult rat hippocampus after an intracerebroventricular kainic acid (KA) administration, a model of temporal lobe epilepsy, leads to permanent loss of the calcium binding protein calbindin in major fractions of dentate gr
Temporal lobe epilepsy (TLE) is one of the most commonly occurring and most intractable forms of seizure disorders in humans. The fundamental mechanisms underlying the pathogenesis of the disorder have, however, not yet been elucidated. El is an inbred mouse strain with genetic predisposition to epi