Imaging in photodynamic therapy

✍ Scribed by Michael R. Hamblin, Yingying Huang

• Publisher: CRC Press
• Year: 2017
• Tongue: English
• Leaves: 502
• Series: Series in cellular and clinical imaging
• Edition: 1
• Category: Library

✦ Synopsis

This book covers the broad field of cellular, molecular, preclinical, and clinical imaging either associated with or combined with photodynamic therapy (PDT). It showcases how this approach is used clinically for cancer, infections, and diseases characterized by unwanted tissue such as atherosclerosis or blindness. Because the photosensitizers are also fluorescent, the book also addresses various imaging systems such as confocal microscopy and small animal imaging systems, and highlights how they have been used to follow and optimize treatment, and to answer important mechanistic questions. Chapters also discuss how imaging has made important contributions to clinical outcomes in skin, bladder, and brain cancers, as well as in the development of theranostic agents for detection and treatment of disease. This book provides a resource for physicians and research scientists in cell biology, microscopy, optics, molecular imaging, oncology, and drug discovery.

✦ Table of Contents

Content: Looking out the optical window : physical principles and instrumentation of imaging in photodynamic therapy / Hui Liu and Jonathan P. Celli --
Photochemistry and photophysics of PDT and photosensitizers / Marcin Ptaszek --
Phthalocyanines in photodynamic therapy / Heidi Abrahamse --
Singlet oxygen luminescence imaging : a prospective tool in bioscience? / Michael Pfitznera, Jan C. Schlothauera, Buhong Lib, and Beate Röder --
Microbial biofilms and antimicrobial photodynamic therapy / Anil Kishen --
High-content imaging for photosensitizer screening / Gisela M.F. Vaz, Mathias O. Senge, Sarah-Louise Ryan, and Anthony Davies --
Enhanced efficacy of photodynamic therapy (PDT) via an iron-lysosome-mitochondria connection : studies with phthalocyanine 4 / Anna-Liisa Nieminen, Hsin-I Hung, and John J. Lemasters --
Role of cell death pathways in response to photodynamic therapy in gliomas / Leonardo Barcelos de Paula, Fernando Lucas Primo, and Antonio Claudio Tedesco --
In the search of specific PDT photosensitizers : subcellular localization and cell death pathways / Tayana M. Tsubonea, Christiane Pavanib, Isabel O.L. Bacellara, and Maurício S. Baptistaa --
Quantum dots in PDT / Ricardas Rotomskis and Giedre Streckytea --
MRI : PDT theranostics tetrapyrrole-based theranostic combinations of photodynamic action and magnetic resonance imaging / Duygu Aydin Tekdas, Devrim Atilla, Vefa Ahsen, and Ayse Gül Gürek --
Theranostic applications of photodynamic molecular beacons / Wentao Song, Yang Zhou, and Jonathan F. Lovell --
Tumor specific imaging and photodynamic therapy targeting the urokinase receptor / Zafar Iqbal, Longguang Jiang, Zhuo Chen, Cai Yuan, Rui Li, Ke Zheng, Xiaolei Zhou, Jjincan Chen, Ping Hu, and Mingdong Huang --
Vascular imaging in photodynamic therapy / Bin Chen --
Photosensitizer activity imaging on the microscopic scale / Steffen Hackbarth --
Bioluminescence imaging for monitoring the effectiveness of photodynamic therapy for infections in animal models / Pawel Mroz and Michael R Hamblin --
Imaging of photosensitizers in skin / Marica B. Ericson, Danni Wang, Despina Kantere, John Paoli, and Ann-Marie Wennberg --
Brain tumor imaging with ALA / Herbert Stepp and Oliver Schnell --
PDT of non-muscle-invasive bladder cancer with hexylester aminolevulinate : optimization of the illumination wavelengths by fluorescence spectroscopy and imaging / Matthieu Zellweger, Claude-André Porret, Norbert Lange, Patrice Jichlinski, Hubert van den Bergh and Georges Wagnières --
Endoscopic imaging and photodynamic therapy / Harubumi Kato, Kinya Furukawa, Jitsuo Usuda, Kuniharu Miyajima and Keishi Ohtani --
Spectroscopic imaging in prostate PDT / Rozhin Penjweini, Brian C. Wilson, and Timothy C. Zhu --
Fluorescent-guided resection in clinical oncology / Ron R. Allison.

✦ Subjects

Photochemotherapy;Photochemotherapy;methods;Photosensitizing Agents;therapeutic use