Resistance to Photodynamic Therapy in Ca
โ Rapozzi, Valentina (Editor), Jori, Giulio (Editor)
๐ Library
๐
2015
๐ Springer
๐ English
โฆ LIBER โฆ
๐
Resistance to Photodynamic Therapy in Cancer
โ Scribed by Valentina Rapozzi, Giulio Jori (eds.)
- Publisher
- Springer International Publishing
- Year
- 2015
- Tongue
- English
- Leaves
- 251
- Series
- Resistance to Targeted Anti-Cancer Therapeutics 5
- Edition
- 1
- Category
- Library
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โฆ Synopsis
This volume provides a comprehensive review of resistance induced by photodynamic therapy (PDT) in tumor cells. Understanding the underlying mechanisms in this process leads to the improvement of therapeutic modality, in combination with chemotherapy, immunotherapy, and radiotherapy. Photodynamic therapy is a minimally invasive therapeutic procedure that can exert a selective or preferential cytotoxic activity toward malignant cells. The procedure involves administration of an intrinsically non-toxic photosensitizing agent (PS) followed by irradiation at a wavelength corresponding to a visible absorption band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Studies reveal that PDT can be curative, particularly in early stage tumors and this volume explores the potential of PDT, but also reveals strategic approaches to overcome resistance in tumor cells.
โฆ Table of Contents
Front Matter....Pages i-xv
Front Matter....Pages 1-1
Basic and Clinical Aspects of Photodynamic Therapy....Pages 3-26
Front Matter....Pages 27-27
Mechanisms of Resistance to Photodynamic Therapy: An Update....Pages 29-63
Tumor Microenvironment as a Determinant of Photodynamic Therapy Resistance....Pages 65-97
Autophagy Induced by Photodynamic Therapy (PDT): Shaping Resistance Against Cell Death and Anti-Tumor Immunity....Pages 99-116
Isolation and Initial Characterization of Resistant Cells to Photodynamic Therapy....Pages 117-145
Front Matter....Pages 147-147
GRP78-targeting Sensitizes Cancer Cells to Cytotoxic Effects of Photodynamic Therapy....Pages 149-161
Optimization of Photodynamic Therapy Response by Survivin Gene....Pages 163-182
Cellular Targets and Molecular Responses Associated with Photodynamic Therapy....Pages 183-193
Front Matter....Pages 195-195
How Nanoparticles Can Solve Resistance and Limitation in PDT Efficiency....Pages 197-211
Mechanisms of Tumor Cell Resistance to ALA-PDT....Pages 213-228
Melanoma Resistance to Photodynamic Therapy....Pages 229-246
Erratum....Pages E1-E1
Back Matter....Pages 247-248
โฆ Subjects
Cancer Research; Drug Resistance; Molecular Medicine
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