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IL-7-enhanced T-cell response to myelin proteins in multiple sclerosis

✍ Scribed by E Traggiai; T Biagioli; E Rosati; C Ballerini; B Mazzanti; A Ben Nun; L Massacesi; M Vergelli


Book ID
114137495
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
98 KB
Volume
121
Category
Article
ISSN
0165-5728

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In order to explore the T-cell repertoire to myelin basic protein (BP) of both multiple sclerosis (MS) patients and healthy subjects (HS), we raised BP reactive T-cell lines from blood mononuclear cells of eight MS patients and five HS. These lines were triggered in vitro by human BP. When analyzing

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## Abstract Oligodendrocyte‐specific protein (OSP) is concentrated in CNS myelin and is a potential autoantigen in the development of multiple sclerosis (MS). We performed proliferation assays with lymphocytes from MS patients and normal controls. OSP peptide‐induced proliferation was common in rel