IL-7-enhanced T-cell response to myelin proteins in multiple sclerosis
β Scribed by E Traggiai; T Biagioli; E Rosati; C Ballerini; B Mazzanti; A Ben Nun; L Massacesi; M Vergelli
- Book ID
- 114137495
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 98 KB
- Volume
- 121
- Category
- Article
- ISSN
- 0165-5728
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π SIMILAR VOLUMES
In order to explore the T-cell repertoire to myelin basic protein (BP) of both multiple sclerosis (MS) patients and healthy subjects (HS), we raised BP reactive T-cell lines from blood mononuclear cells of eight MS patients and five HS. These lines were triggered in vitro by human BP. When analyzing
T cell lines and clones specific for human myelin basic protein (BP) were selected from three multiple sclerosis (MS) patients and two healthy subjects and tested for their proliferative responses to a battery of synthetic peptides, 9 to 21 amino acid residues long. The combined amino acid sequence
## Abstract Oligodendrocyteβspecific protein (OSP) is concentrated in CNS myelin and is a potential autoantigen in the development of multiple sclerosis (MS). We performed proliferation assays with lymphocytes from MS patients and normal controls. OSP peptideβinduced proliferation was common in rel