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IL-6 augments angiotensinogen in primary cultured renal proximal tubular cells

✍ Scribed by Ryousuke Satou; Romer A. Gonzalez-Villalobos; Kayoko Miyata; Naro Ohashi; Maki Urushihara; Omar W. Acres; L. Gabriel Navar; Hiroyuki Kobori


Book ID
116734601
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
707 KB
Volume
311
Category
Article
ISSN
0303-7207

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## Abstract Cyclosporine A (CsA) is known to have direct toxicity to renal tubular cells. Its toxicity may be mediated by intracellular calcium because CsA increases intracellular calcium concentration and enhances the activities of calcium‐dependent calpains and caspases. Calbindin‐D~28k~, a cytos