## Abstract Cyclosporine A (CsA) is known to have direct toxicity to renal tubular cells. Its toxicity may be mediated by intracellular calcium because CsA increases intracellular calcium concentration and enhances the activities of calciumβdependent calpains and caspases. CalbindinβD~28k~, a cytos
Difference in H2O2 toxicity between intact renal tubules and cultured proximal tubular cells
β Scribed by Yong Keun Kim; Sun Hee Ko; Jae Suk Woo; Sang Ho Lee; Jin Sup Jung
- Book ID
- 113994163
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 416 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0006-2952
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π SIMILAR VOLUMES
Cl(-) /HCO (3)(-) exchanger and Na(+) /H(+) exchanger 3 are the main transporters responsible for NaCl reabsorption in kidney proximal tubules (PT). It is well accepted that membrane exchangers can be regulated by reactive oxygen species (ROS). In the kidney, ROS are known to contribute to decreases
## Abstract Both oxidative stress and epidermal growth factor (EGF) contribute to the initiation and progression of renal proximal tubular dysfunction under pathophysiologic conditions. Thus, this study was performed (1) to examine both the individual, and the combined effects of H~2~O~2~ and EGF o