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IL-3 and GM-CSF induce the expression of the inositol trisphosphate receptor in K562 myeloblast cells

✍ Scribed by Peter G. Bradford; Youyu Jin; Pei Hui; Xioahong Wang


Book ID
117055694
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
517 KB
Volume
187
Category
Article
ISSN
0006-291X

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The AML14.3D10 human myeloid leukemic cell line expresses receptors for granulocytemacrophage colony stimulating factor (GM-CSF) and interleukin-5 (IL-5), but not IL-3. We have found that this cell line produces GM-CSF in amounts up to 113 pg/ml in culture supernatants. Deprivation of endogenous GM-