## Background: The IL23/IL17 pathway is pivotal in the development of chronic mucosal inflammation seen in Crohn's disease (CD). Genetic variants in the IL23R and IL12B have been associated with CD susceptibility. We investigated 10 genes within the IL23/IL17 pathway in a case-control study of 763
IL-23/IL-17 immunity as a hallmark of Crohn's disease
✍ Scribed by Veera Hölttä; Paula Klemetti; Taina Sipponen; Mia Westerholm-Ormio; Guillermo Kociubinski; Harri Salo; Laura Räsänen; Kaija-Leena Kolho; Martti Färkkilä; Erkki Savilahti; Outi Vaarala
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 151 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1078-0998
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✦ Synopsis
Background:
We studied the balance between ileal T-effector cells versus T-regulatory cells in active and inactive Crohn's disease (CD).
Methods:
We compared effector and regulatory T-cell-related
📜 SIMILAR VOLUMES
Mann-Whitney U-test were used for statistical analysis. A total of 618 IBD patients (CD 485, UC 125, indeterminate colitis [IC] 8) were included in our study (Table 1). Venous TE was diagnosed in 38 (6.2%) patients (CD 27, UC 11). Distribution of gender and diagnosis of IBD (CD, UC, or IC) did not
## Background: The IL-23 pathway plays a pivotal role in the development of chronic mucosal inflammation seen in the inflammatory bowel diseases. Multiple studies have now established the contribution of the interleukin 23 receptor gene (IL23R) to Crohn's disease (CD) risk in general and of the IL2
## Background: We analyzed the influence of Crohn's disease (CD)associated IL23R gene variants on IL-22 that is expressed in IL-23Rϩ Th17 cells. Methods: IL-22 serum levels were measured in 242 CD patients and in 31 healthy controls. Subanalyses included serum levels of IL-6, TNF-␣, IL-17A, IL-17
Background: Tumor necrosis factor (TNF)-like protein 1A (TL1A) is a member of the TNF superfamily and contributes to the pathogenesis of Crohn's disease (CD) by stimulating T-helper (Th) 1 cells. In addition to Th1, recent studies have focused on the role of Th17 cells in the pathogenesis of CD. Her