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IL-17 inhibits human Th1 differentiation through IL-12Rβ2 downregulation

✍ Scribed by Myew-Ling Toh; Masanori Kawashima; Saloua Zrioual; Arnaud Hot; Philippe Miossec; Pierre Miossec


Book ID
116398842
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
419 KB
Volume
48
Category
Article
ISSN
1043-4666

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## Abstract The cytokines IL‐6, IL‐1β, TGF‐β, and IL‐23 are considered to promote Th17 commitment. Langerhans cells (LC) represent DC in the outer skin layers of the epidermis, an environment extensively exposed to pathogenic attack. The question whether organ‐resident DC like LC can evoke Th17 imm