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IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways

✍ Scribed by Sue-Yun Hwang, Ju-Young Kim, Kyoung-Woon Kim, Mi-Kyung Park…


Book ID
120707042
Publisher
BioMed Central
Year
2004
Tongue
English
Weight
180 KB
Volume
6
Category
Article
ISSN
1478-6354

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## Abstract High mobility group box chromosomal protein 1 (HMGB‐1) is a widely studied, ubiquitous nuclear protein that is present in eukaryotic cells, and plays a crucial role in inflammatory response. However, the effects of HMGB‐1 on human synovial fibroblasts are largely unknown. In this study,