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CCN4 induces IL-6 production through αvβ5 receptor, PI3K, Akt, and NF-κB singling pathway in human synovial fibroblasts

✍ Scribed by Chun-Han Hou, Chih-Hsin Tang, Chin-Jung Hsu, Sheng-Mon Hou…


Book ID
120705222
Publisher
BioMed Central
Year
2013
Tongue
English
Weight
970 KB
Volume
15
Category
Article
ISSN
1478-6354

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HMGB-1 induces IL-6 production in human
✍ Chun-Han Hou; Yi-Chin Fong; Chih-Hsin Tang 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 589 KB

## Abstract High mobility group box chromosomal protein 1 (HMGB‐1) is a widely studied, ubiquitous nuclear protein that is present in eukaryotic cells, and plays a crucial role in inflammatory response. However, the effects of HMGB‐1 on human synovial fibroblasts are largely unknown. In this study,