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IL-10 production by B cells is differentially regulated by immune-mediated and infectious stimuli and requires p38 activation

✍ Scribed by Mion, Francesca; Tonon, Silvia; Toffoletto, Barbara; Cesselli, Daniela; Pucillo, Carlo E.; Vitale, Gaetano


Book ID
125847944
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
832 KB
Volume
62
Category
Article
ISSN
0161-5890

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## Abstract We have shown that the bacterial iron chelator, deferoxamine (DFO), triggers inflammatory signals including the production of CXC chemokine IL‐8, in human intestinal epithelial cells (IECs) by activating the ERK1/2 and p38 kinase pathways. In this study we investigated the mechanisms in