✦ LIBER ✦

Ignorability and bias in clinical trials

✍ Scribed by Daniel F. Heitjan

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 123 KB
Volume: 18
Category: Article
ISSN: 0277-6715
DOI: 10.1002/(sici)1097-0258(19990915/30)18:17/18<2421::aid-sim266>3.0.co;2-r

No coin nor oath required. For personal study only.

✦ Synopsis

Patient non-compliance and drop-out can bias analyses of clinical trial data. I describe a parametric model for treatment cross-over and drop-out and demonstrate how the concept of ignorability, originally de"ned for incomplete-data problems, can elucidate sources of bias in clinical trials. I discuss some implications of the theory and present simulation examples that illustrate the potential e!ects of non-ignorable cross-over and drop-out on bias and power.

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