IgG and IgA antibodies to the collagen-like region of C1q in rheumatoid vasculitis

✍ Scribed by C. E. H. Siegert; M. R. Daha; E. A. M. Der Van Voort; F. C. Breedveld

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 780 KB
• Volume: 33
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780331107

✦ Synopsis

We investigated the presence of IgG and IgA antibodies to Clq in serum samples from 80 patients with rheumatoid arthritis (RA), 31 patients with rheumatoid vasculitis, and 80 healthy controls. IgG and IgA antibodies to Clq, as measured by enzyme-linked immunosorbent assay, were found in <5% of the sera from RA patients and from healthy controls. In contrast, IgG and IgA antibodies to Clq were found in 29% and 61%, respectively, of the sera from patients with rheumatoid vasculitis. The occurrence of IgA antibodies to Clq has not been previously demonstrated. These results also demonstrate that IgG antibodies to Clq do not occur exclusively in systemic lupus erythematosus patients: Sera of patients with rheumatoid vasculitis frequently contain IgG or IgA antibodies to Clq, which contribute to immune complex formation.

Monomeric IgG in serum samples from patients with systemic lupus erythematosus (SLE) has been shown to bind Clq (1). There is evidence that sera from patients with systemic lupus erythematosus contain IgG antibodies directed against C lq, in particular, antibodies against the collagen-like region (CLR) of