Evidence for the presence of autoantibodies to the collagen-like portion of c1q in systemic lupus erythematosus
โ Scribed by Ursula Antes; Hans-Peter Heinz; Michael Loos
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 765 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0004-3591
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๐ SIMILAR VOLUMES
Objective. To describe a new kindred with Clq deficiency and to identify the molecular lesions responsible for complete functional Clq deficiency in this and 2 other previously described kindreds. Methods. The A-, B-, and C-chain genes of Clq were amplified by polymerase chain reaction, cloned, and
We investigated the presence of IgG and IgA antibodies to Clq in serum samples from 80 patients with rheumatoid arthritis (RA), 31 patients with rheumatoid vasculitis, and 80 healthy controls. IgG and IgA antibodies to Clq, as measured by enzyme-linked immunosorbent assay, were found in <5% of the s