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Evidence for the presence of autoantibodies to the collagen-like portion of c1q in systemic lupus erythematosus

โœ Scribed by Ursula Antes; Hans-Peter Heinz; Michael Loos


Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
765 KB
Volume
31
Category
Article
ISSN
0004-3591

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๐Ÿ“œ SIMILAR VOLUMES


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Objective. To describe a new kindred with Clq deficiency and to identify the molecular lesions responsible for complete functional Clq deficiency in this and 2 other previously described kindreds. Methods. The A-, B-, and C-chain genes of Clq were amplified by polymerase chain reaction, cloned, and

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We investigated the presence of IgG and IgA antibodies to Clq in serum samples from 80 patients with rheumatoid arthritis (RA), 31 patients with rheumatoid vasculitis, and 80 healthy controls. IgG and IgA antibodies to Clq, as measured by enzyme-linked immunosorbent assay, were found in <5% of the s