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IGF2DMR0 Methylation, Loss of Imprinting, and Patient Prognosis in Esophageal Squamous Cell Carcinoma

✍ Scribed by Murata, Asuka; Baba, Yoshifumi; Watanabe, Masayuki; Shigaki, Hironobu; Miyake, Keisuke; Ishimoto, Takatsugu; Iwatsuki, Masaaki; Iwagami, Shiro; Yoshida, Naoya; Oki, Eiji; Morita, Masaru; Nakao, Mitsuyoshi; Baba, Hideo

Book ID: 125405944
Publisher: Springer
Year: 2013
Tongue: English
Weight: 750 KB
Volume: 21
Category: Article
ISSN: 1068-9265
DOI: 10.1245/s10434-013-3414-7

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## Abstract Previous studies on esophageal squamous cell carcinoma (ESCC) indicated that it contains much dysregulation of microRNAs (miRNAs). DNA hypermethylation in the miRNA 5′ regulatory region is a mechanism that can account for the downregulation of miRNA in tumors (Esteller, N Engl J Med 200