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IGF-1R tyrosine kinase expression and dependency in clones of IGF-1R knockout cells (R−)

✍ Scribed by Linda Rosengren; Daiana Vasilcanu; Radu Vasilcanu; Sandra Fickenscher; Bita Sehat; Nathalia Natalishvili; Sean Naughton; Shucheng Yin; Ada Girnita; Leonard Girnita; Magnus Axelson; Olle Larsson

Book ID
116293293
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
186 KB
Volume
347
Category
Article
ISSN
0006-291X

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## Abstract Wildtype (WT) gastrointestinal stromal tumors (GISTs), lacking mutations in __KIT__ or __PDGFRA__, represent 85% of GISTs in pediatric patients. Treatment options for pediatric WT GIST are limited. Recently, expression profiling of a limited number of pediatric and adult WT GISTs and mo