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IGF-1R, IGF-1 and IGF-2 expression as potential prognostic and predictive markers in colorectal-cancer

✍ Scribed by Gerrit Peters; Silvia Gongoll; Cord Langner; Michael Mengel; Pompiliu Piso; Jürgen Klempnauer; Josef Rüschoff; Hans Kreipe; Reinhard von Wasielewski


Book ID
106116948
Publisher
Springer
Year
2003
Tongue
English
Weight
347 KB
Volume
443
Category
Article
ISSN
1432-2307

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## Background and Objectives: We have previously shown that insulin-like growth factor (IGF)-responsive murine sarcomas demonstrate inhibition of local and metastatic disease growth when implanted in an IGF-deficient host animal. In this experiment, we tested whether IGF receptor (IGF-R) and ligan