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IGF-1 receptor is essential for the establishment of hippocampal neuronal polarity

✍ Scribed by Sosa, Lucas; Dupraz, Sebastian; Laurino, Lisandro; Bollati, Flavia; Bisbal, Mariano; Cáceres, Alfredo; Pfenninger, Karl H; Quiroga, Santiago


Book ID
109940858
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
331 KB
Volume
9
Category
Article
ISSN
1097-6256

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## Abstract Type 1 insulin‐like growth factor receptor (IGF1R) signaling in neuronal development was studied in mutant mice with blunted __igf1r__ gene expression in nestin‐expressing neuronal precursors. At birth [postnatal (P) day 0] brain weights were reduced to 37% and 56% of controls in mice h