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IFN-β induces serine phosphorylation of Stat-1 in Ewing's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7

✍ Scribed by Sancéau, Josiane; Hiscott, John; Delattre, Olivier; Wietzerbin, Juana


Book ID
110063993
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
394 KB
Volume
19
Category
Article
ISSN
0950-9232

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## Abstract Caspases exist as zymogens, and are activated by various extracellular stimuli, leading to apoptosis. One such stimulus is Fas/CD95, a member of the tumor necrosis factor receptor family, providing one means of cytotoxic T lymphocyte (CTL)‐mediated cell lysis. Clinical evidence has show