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Idiopathic dystonia: Neuropharmacological study

✍ Scribed by F. Girotti; G. Scigliano; N. Nardocci; L. Angelini; G. Broggi; P. Giovannini; T. Caraceni

Publisher: Springer
Year: 1982
Tongue: English
Weight: 375 KB
Volume: 227
Category: Article
ISSN: 0340-5354
DOI: 10.1007/bf00313391

No coin nor oath required. For personal study only.

✦ Synopsis

A total of 15 patients affected by idiopathic dystonia (7 with generalized and 8 with focal or segmental dystonia) were subjected to therapy with bromocriptine at low doses, pimozide and trihexyphenidyl. The symptoms were evaluated by giving a progressive score in relation to the intensity of the dystonic symptom to each of the body segments involved by the dystonia. Bromocriptine did not significantly modify the dystonia. Pimozide showed a slight nonsignificant improvement of the dystonic symptoms. Trihexyphenidyl was effective in the generalized dystonias, in agreement with previous reports in the literature. The variation in the pharmacological results could be due to the diversity of the dystonic syndromes, which comprise cases that are different in age at onset, site of dystonic symptoms, and evolution.

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