Age of onset and severity of idiopathic torsion dystonia (ITD) were studied in 100 British families containing 107 index cases and 79 secondary cases. Analysis of variance of these clinical features did not suggest that ITD is genetically heterogenous, and they were similar in Jewish and non-Jewish
A case-control study of idiopathic torsion dystonia
β Scribed by Dr. N. A. Fletcher; A. E. Harding; C. D. Marsden
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 514 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0885-3185
No coin nor oath required. For personal study only.
β¦ Synopsis
A study of 71 patients with idiopathic torsion dystonia (ITD) and 71 matched controls was performed to investigate the range of possible clinical expression of ITD and the role of environmental factors in the development of the disease. A family history of tremor and stuttering were the only factors significantly associated with ITD. No associated environmental factor was identified.
π SIMILAR VOLUMES
## Abstract Idiopathic torsion dystonia (ITD) is a dominantly inherited disorder with incomplete penetrance. It is important to identify factors that may cause dystonia or prevent its occurrence in a genetically predisposed individual. Because dystonia may be precipitated by peripheral triggers, we
## Abstract We reviewed the histories of 115 patients who had idiopathic dystonia and who were 21 years of age and younger at onset of symptoms and 472 patients with older than age 21. Patients with onset in the lower extremities tended to be younger at onset (mean age 8.4 years), have rapid spread
Carpal tunnel syndrome (CTS) is usually an idiopathic disorder. Certain occupations that require frequent flexion movements of the hand at the wrist are recognized as precipitating the development of CTS. Dystonia can cause similar excessive movements at the wrists. We report the clinical and electr
## Abstract Although childhood, limbβonset idiopathic torsion dystonia (ITD) is at increased prevalence among Jews, and Ashkenazi Jews with this form of ITD show linkage disequilibrium for a unique haplotype, little else is known about phenotypic or genetic variation in ITD among ethnic groups. We