The parental origin and mechanism of formation of polysomy X were studied in five cases (one case of 49,XXXXX; four cases of 49,XXXXY), using various X-linked restriction fragment length polymorphisms as genetic markers. Segregation and densitometric analyses on the polymorphic DNA fragments reveale
Identification of the parental origin of polysomy in two 49,XXXXY cases
✍ Scribed by Arzu Çelik; Serpil Eraslan; Nalan Gökgöz; Hatice Ilgin; Seher Baçaran; Işik Bökesoy; Hülya Kayserili; Memnune Yüksel-Apak; Betül Kirdar
- Book ID
- 110887646
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 536 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0009-9163
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Five polymorphic index markers were analyzed by polymerase chain reaction (PCR) to ascertain the parental origin of the extra X chromosomes in seven polysomic cases (one 49,XXXXX, three 49,XXXXY, two 48,XXXY, and one 48,XXYY). All four X chromosomes in 49, X polysomies were maternal in origin and th
We present a patient with a 49,XXXXY chromosome constitution in whom the origin of the extra X chromosomes was determined by analysis of five polymorphic CA (or GT) dinucleotide repeat sequences. This class of DNA marker has recently been demonstrated to be hypervariable with heterozygosity values u