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Identification of the orphan GPCR, P2Y10 receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor

โœ Scribed by Masanori Murakami; Akira Shiraishi; Kenichi Tabata; Norihisa Fujita


Book ID
116296800
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
755 KB
Volume
371
Category
Article
ISSN
0006-291X

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In Xenopus oocytes, both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) activate Ca2+-dependent oscillatory Cl- currents by acting through membrane-bound receptors. External application of 50 microM S1P elicited a long-lasting oscillatory current that continued over 30 min from the be