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Identification of the Low Density Lipoprotein Receptor-Related Protein (LRP) as an Endocytic Receptor for Thrombospondin-1

โœ Scribed by Svetlana Godyna, Gene Liau, Ileana Popa, Steingrimur Stefansson and W. Scott Argraves

Book ID
124777829
Publisher
Rockefeller University Press.
Year
1995
Tongue
English
Weight
494 KB
Volume
129
Category
Article
ISSN
0021-9525

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Thrombospondin-1 inhibits VEGF levels in
Thrombospondin-1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor-related protein-1 (LRP-1)
โœ James Greenaway; Jack Lawler; Roger Moorehead; Paul Bornstein; Jonathan LaMarre; ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 544 KB

## Abstract VEGF is a potent proโ€angiogenic factor whose effects are opposed by a host of antiโ€angiogenic proteins, including thrombospondinโ€1 (TSPโ€1). We have previously shown that VEGF has important extravascular roles in the ovary and that VEGF and TSPโ€1 are inversely expressed throughout the ov