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Identification of the human ERK gene as a putative receptor tyrosine kinase and its chromosomal localization to 1p36.1: a comparative mapping of human, mouse, and rat chromosomes

✍ Scribed by Toshiyuki Saito; Naohiko Seki; Yoichi Matsuda; Makoto Kitahara; Motoi Murata; Naotoshi Kanda; Nobuo Nomura; Tadashi Yamamoto; Tada-aki Hori


Book ID
116154132
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
275 KB
Volume
26
Category
Article
ISSN
0888-7543

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The protein designated as insulin receptor substrate-1 (IRS-1) is a major substrate for the insulin receptor tyrosine kinase. Since post-receptor defects in the insulin signalling pathway are a common feature of Type 2 (noninsulin-dependent) diabetes mellitus, we have cloned the human IRS-1 gene in