Identification of the histamine H1 receptor gene as a differentially repressed target of the human TR2 orphan receptor
β Scribed by Han Jung Lee; Yi-Fen Lee; Chawnshang Chang; Chawnshang Chang
- Book ID
- 110242847
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 76 KB
- Volume
- 194
- Category
- Article
- ISSN
- 0300-8177
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We have assigned the human histamine H1-receptor gene to chromosome 3 by Southern blot analysis of a chromosome mapping panel constructed from human-hamster somatic cell hybrids. This assignment was confirmed by in situ hybridization on metaphase chromosomes and involved bands 3p14-p21.
## Abstract Histamine H~1~ antagonists or βantihistaminesβ are one of the most prescribed drug families in Western countries. They exert their effect by binding to the histamine H~1~ receptor, a receptor belonging to the class of rhodopsinβlike G proteinβcoupled receptors (GPCRs). In this review, t