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Identification of the chromosome 12 translocation breakpoint region of a pleomorphic salivary gland adenoma with t(1;12)(p22;q15) as the sole cytogenetic abnormality

✍ Scribed by Patrick F.J. Kools; Sylke Wanschura; Eric F.P.M. Schoenmakers; Jan M.W. Geurts; Raf Mols; Bernd Kazmierczak; Jörn Bullerdiek; Herman Van Den Berghe; Wim J.M. Van de Ven


Book ID
113253352
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
611 KB
Volume
79
Category
Article
ISSN
0165-4608

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A subgroup of pleomorphic adenomas of the salivary glands is characterized by translocations involving chromosome 8, with consistent breakpoints at 8q 12. As part of a positional cloning effort to isolate the gene(s) affected by these translocations we now report the mapping of the 8q I 2 breakpoint