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Identification of the auto-inhibitory domains of Aurora-A kinase

✍ Scribed by Yue Zhang; Jun Ni; Qiang Huang; Weihua Ren; Long Yu; Shouyuan Zhao

Book ID
116294720
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
461 KB
Volume
357
Category
Article
ISSN
0006-291X

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## Abstract Aurora‐A is an oncogenic kinase that plays essential roles in mitosis as well as cell survival. Aurora‐A interacting protein (AIP) was identified as a negative regulator of Aurora‐A with its ectopic over expression inducing destabilization of Aurora‐A protein. Here we present evidence t