The Lck protein (p56 lck ), a src family tyrosine kinase essential for T cell development and function, is aberrantly expressed in various types of cancers. We revealed recently that Lck can be a tumor antigen recognized by HLA-A24restricted and tumor-specific cytotoxic T lymphocytes (CTLs) of cance
Identification of SART3-derived peptides capable of inducing HLA-A2-restricted and tumor-specific CTLs in cancer patients with different HLA-A2 subtypes
β Scribed by Masaaki Ito; Shigeki Shichijo; Yoshiaki Miyagi; Terutada Kobayashi; Naotake Tsuda; Akira Yamada; Norio Saito; Kyogo Itoh
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- French
- Weight
- 141 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
We have described the SART-1 gene-encoding peptides recognized by HLA-A2601-restricted and tumor-specific cytotoxic T lymphocytes (CTLs). We now have investigated whether SART-1 encodes peptides capable of inducing the HLA-A24-restricted CTLs. Among the 18 different peptides with HLA-A24-binding mot
## Abstract To identify CTLβdirected antigens in gastrointestinal cancer, we have investigated antigens recognized by the HLAβA2βrestricted CTL line established from T cells infiltrating into colon cancer and report herein cleavage and polyadenylation specificity factor (CPSF) as a potent antigen h
## Background and objectives: Using peripheral blood mononuclear cells (pbmcs) from a 10-year survivor with established human leukocyte antigen (hla)-a2(+) and mage-3(+) esophageal cancer cell line (kyse-170), we examined the induction of hla-a2-restricted and mage-3-gene-derived peptide (flwgpralv
To generate non-small cell lung cancer (NSCLC)-reactive lymphocytes, we transfected an HLA-A2-expressing human NSCLC line (1355) with the cDNA encoding the lymphocyte co-stimulatory molecule CD80. Following selection in G418, 1355.7 demonstrated stable cell-surface expression of CD80. Allogeneic mix