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Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells

✍ Scribed by Lee, Seung-Woo; Park, Yunji; So, Takanori; Kwon, Byoung S; Cheroutre, Hilde; Mittler, Robert S; Croft, Michael


Book ID
118676054
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
803 KB
Volume
9
Category
Article
ISSN
1529-2908

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## Abstract 4‐1BBL^–/–^ mice have a defect in recall CD8^+^ T cell responses to viruses, whereas CD4^+^ T cell responses to virus are unimpaired in these mice. In contrast, both CD4^+^ and CD8^+^ T cells respond to 4‐1BB ligand (4‐1BBL) __in vitro__. To clarify the role of 4‐1BB/4‐1BBL in CD4^+^ ve