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Identification of p21 (CIP1/WAF1) as a direct target gene of HIC1 (Hypermethylated In Cancer 1)

✍ Scribed by Dehennaut, Vanessa; Loison, Ingrid; Boulay, Gaylor; Van Rechem, Capucine; Leprince, Dominique

Book ID
122386739
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
519 KB
Volume
430
Category
Article
ISSN
0006-291X

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In addition to the tumor suppressor gene p53, Cyclin Dependent Kinases (CDK) are well known to influence the cell cycle in normal human tissues and various neoplasias as well. The purpose of our present study was to evaluate the expression of the CDK-inhibitor p21/waf1/cip1 in colorectal cancer with