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Identification of ozone-oxidation products of oxycodone by electrospray ion trap mass spectrometry

✍ Scribed by Keijo Pennanen; Tapio Kotiaho; Katri Huikko; Risto Kostiainen

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
167 KB
Volume
36
Category
Article
ISSN
1076-5174

No coin nor oath required. For personal study only.

✦ Synopsis

The products of oxycodone oxidized by ozone were characterized by electrospray ionization-tandem mass spectrometry (ESI--MS/MS). Liquid Chromatography(LC)--MS analyses revealed that the main constituents in the oxidation reaction mixture included the protonated molecules m/z 316, corresponding to oxycodone, and m/z 332, m/z 348, m/z 366, corresponding to the oxidation products. ESI--MS/MS and MS(n) spectra were used to study oxycodone fragmentation in detail and to characterize the structures of oxidation products. The results show that the oxidation products were formed by addition of one or two oxygen atoms or by addition of three oxygen and two hydrogen atoms to oxycodone. The fragmentation of the oxidation products also shows that the aromatic ring oxidizes due to rupture of the C-3--C-4 bond during product formation.

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