Identification of novel transcript variants of estrogen receptor α, β and progesterone receptor gene in human endometrium
✍ Scribed by Anette Springwald; Claus Lattrich; Maciek Skrzypczak; Regina Goerse; Olaf Ortmann; Oliver Treeck
- Book ID
- 107571420
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 470 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0969-711X
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We have carried out a quantitative analysis of ER-alpha and ER-beta mRNA expression in normal (n = 11) and breast cancer (n = 112) tissues using a real-time (Taq-Man) PCR assay. Expression of ER-beta mRNA variants has also been studied by triple-primer PCR assay. ER-alpha mRNA levels in normal breas
## Abstract Endometrial cancer is well known to be estrogen‐dependent. Two estrogen receptor types, ERα and ERβ, are major mediators of a diversity of biologic functions of estrogen and play an important role in estrogen‐dependent tissues and cancers. Cloning of ERβ was followed by the discovery of