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Effects of exon-deleted estrogen receptor β transcript variants on growth, apoptosis and gene expression of human breast cancer cell lines

✍ Scribed by Oliver Treeck; Ingolf Juhasz-Boess; Claus Lattrich; Felicitas Horn; Regina Goerse; Olaf Ortmann

Publisher: Springer US
Year: 2007
Tongue: English
Weight: 577 KB
Volume: 110
Category: Article
ISSN: 0167-6806
DOI: 10.1007/s10549-007-9749-7

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## Abstract Although tamoxifen (TAM) is used for the front‐line treatment and prevention of estrogen receptor‐positive (ER+) breast tumors, nearly 40% of estrogen‐dependent breast tumors do not respond to TAM treatment. Moreover, the positive response is usually of short duration, and most tumors e