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Identification of novel sites in the ovine growth hormone receptor involved in binding hormone and conferring species specificity

✍ Scribed by Gordon J. Allan; John H. Shand; James Beattie; David J. Flint

Book ID
114429807
Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
671 KB
Volume
261
Category
Article
ISSN
1432-1327

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Binding of growth hormone (GH) to its receptor (GHR) is a well-studied example of molecular recognition between a cytokine and its receptor. Extensive mutagenesis studies and several crystal structures have defined the key interactive amino acid residues that are involved in binding and subsequent r