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Identification of novel SIRT2-selective inhibitors using a click chemistry approach

✍ Scribed by Tatum, Prima R.; Sawada, Hideyuki; Ota, Yosuke; Itoh, Yukihiro; Zhan, Peng; Ieda, Naoya; Nakagawa, Hidehiko; Miyata, Naoki; Suzuki, Takayoshi


Book ID
125466089
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
999 KB
Volume
24
Category
Article
ISSN
0960-894X

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We report the identification of a novel NR2B-selective NMDAR antagonist with an original scaffold, LSP10-0500. This compound was identified by a virtual high-throughput screening approach on the basis of a quantitative pharmacophore model of NR2B-specific NMDAR antagonists. A SAR study around LSP10-