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Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94

โœ Scribed by Feixia Chu; Jason C. Maynard; Gabriela Chiosis; Christopher V. Nicchitta; Alma L. Burlingame

Book ID
111752684
Publisher
Cold Spring Harbor Laboratory Press
Year
2006
Tongue
English
Weight
622 KB
Volume
15
Category
Article
ISSN
0961-8368

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Geldanamycin, a benzoquinone ansamycin, binds specifically to hsp90 and GRP94 in vitro and in vivo. Treatment of cells with geldanamycin alters the molecular chaperone function of hsp90, and as a result, blocks certain cytosolic proteins from reaching their mature form, inhibits their activity, and/