Structural Transitions Accompanying the Activation of Peptide Binding to the Endoplasmic Reticulum Hsp90 Chaperone GRP94 †

Geldanamycin, an hsp90/GRP94-binding dru

Geldanamycin, an hsp90/GRP94-binding drug, induces increased transcription of endoplasmic reticulum (ER) chaperones via the ER stress pathway

✍ Beth Lawson; Joseph W. Brewer; Linda M. Hendershot 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 241 KB 👁 1 views

Geldanamycin, a benzoquinone ansamycin, binds specifically to hsp90 and GRP94 in vitro and in vivo. Treatment of cells with geldanamycin alters the molecular chaperone function of hsp90, and as a result, blocks certain cytosolic proteins from reaching their mature form, inhibits their activity, and/