Identification of novel estrogen receptor α antagonists
✍ Scribed by Dalei Shao; Thomas J Berrodin; Eric Manas; Diane Hauze; Robert Powers; Ashok Bapat; Daniel Gonder; Richard C Winneker; Donald E Frail
- Book ID
- 116697287
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 369 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0960-0760
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Two distinct families of small molecules were discovered as novel alpha7 nicotinic acetylcholine receptor (nAChR) antagonists by pharmacophore-based virtual screening. These novel antagonists exhibited selectivity for the neuronal alpha7 subtype over other nAChRs and good brain penetration. Neuropro
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