## Abstract ## Background. Oral squamous cell carcinoma (OSCC) is caused by multiple factors, including carcinogen exposure. Insulinβlike growth factor II mRNAβbinding protein 3 (IMP3) is highly expressed in various cancer cells but is rarely expressed in normal cells. We investigated whether IMP3
Identification of insulin-like growth factor 2 mRNA-binding protein 3 as a radioresistance factor in squamous esophageal cancer cells
β Scribed by K. Yoshino; S. Motoyama; S. Koyota; K. Shibuya; Y. Sato; T. Sasaki; A. Wakita; H. Saito; Y. Minamiya; T. Sugiyama; J. Ogawa
- Book ID
- 117949114
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 626 KB
- Volume
- 27
- Category
- Article
- ISSN
- 1120-8694
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The mitogenic effects of insulin-like growth factors (IGFs) are regulated by a family of insulin-like growth factor binding proteins (IGFBPs). One member of this family, IGFBP-3, mediates the growth-inhibitory and apoptosis-inducing effects of a number of growth factors and hormones such as transfor
## Abstract The insulinβlike growth factor (IGF) axis is a complex system composed of 2 mitogenic ligands, IGFβI and βII, 2 receptors, IGFβ1R and IGFβ2R, and 6 binding proteins, IGFBPβ1 to β6. The IGFBPs exert their actions through their regulation of IGF bioavailability for IGF receptors. In addit