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Identification of germline MLH1 alterations in familial prostate cancer

✍ Scribed by H. Fredriksson; T. Ikonen; V. Autio; M.P. Matikainen; H.J. Helin; T.L.J. Tammela; P.A. Koivisto; J. Schleutker


Book ID
116429030
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
150 KB
Volume
42
Category
Article
ISSN
0959-8049

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Identification of six novel MSH2 and MLH
✍ Stefan KrΓΌger; Jens Plaschke; Birgit Jeske; Heike GΓΆrgens; Steffen R. Pistorius; πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 40 KB πŸ‘ 2 views

Germline mutations in mismatch repair genes are responsible for hereditary nonpolyposis colorectal cancer (HNPCC), the most common hereditary cancer-susceptibility syndrome. We report six novel germline mutations, three in MSH2 and three in MLH1. All but one mutation have been found in families fulf